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Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactio...

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Publicat a:Chem Sci
Autors principals: Almond-Thynne, Joshua, Blakemore, David C., Pryde, David C., Spivey, Alan C.
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304707/
https://ncbi.nlm.nih.gov/pubmed/28451148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02118b
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