VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

di Lin, Kai, Perni, Robert B., Kwong, Ann D., Lin, Chao
Pubblicazione 2006

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

di King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Samuel C., Otto, Michael J.
Pubblicazione 1999

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

di King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Sameul C., Otto, Michael J.
Pubblicazione 1998

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR

di Dai, Han, Kustigian, Lauren, Carney, David, Case, April, Considine, Thomas, Hubbard, Basil P., Perni, Robert B., Riera, Thomas V., Szczepankiewicz, Bruce, Vlasuk, George P., Stein, Ross L.
Pubblicazione 2010

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

di Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.
Pubblicazione 2009

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

di Jin, Lei, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Morrison, Michael, Xia, Yu, Wang, Xiaohong, Xu, Yihua, Yang, Yuecheng, Smith, Jesse J, Hoffmann, Ethan, Carney, David P, Perni, Robert B, Jirousek, Michael R, Bemis, Jean E, Milne, Jill C, Sinclair, David A, Westphal, Christoph H
Pubblicazione 2009

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

di Perni, Robert B., Almquist, Susan J., Byrn, Randal A., Chandorkar, Gurudatt, Chaturvedi, Pravin R., Courtney, Lawrence F., Decker, Caroline J., Dinehart, Kirk, Gates, Cynthia A., Harbeson, Scott L., Heiser, Angela, Kalkeri, Gururaj, Kolaczkowski, Elaine, Lin, Kai, Luong, Yu-Ping, Rao, B. Govinda, Taylor, William P., Thomson, John A., Tung, Roger D., Wei, Yunyi, Kwong, Ann D., Lin, Chao
Pubblicazione 2006

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

di Milne, Jill C., Lambert, Philip D., Schenk, Simon, Carney, David P., Smith, Jesse J., Gagne, David J., Jin, Lei, Boss, Olivier, Perni, Robert B., Vu, Chi B., Bemis, Jean E., Xie, Roger, Disch, Jeremy S., Ng, Pui Yee, Nunes, Joseph J., Lynch, Amy V., Yang, Hongying, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Iffland, Andre, Lavu, Siva, Medvedik, Oliver, Sinclair, David A., Olefsky, Jerrold M., Jirousek, Michael R., Elliott, Peter J., Westphal, Christoph H.
Pubblicazione 2007

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

di Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Pubblicato in Nat Commun (2015)

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

di Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Sook Yen, E, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Pubblicazione 2013