Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

door Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Zennou, Veronique, Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2011

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

door King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Samuel C., Otto, Michael J.
Gepubliceerd in 1999

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

door King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Sameul C., Otto, Michael J.
Gepubliceerd in 1998

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

door Mosley, Ralph T., Edwards, Thomas E., Murakami, Eisuke, Lam, Angela M., Grice, Rena L., Du, Jinfa, Sofia, Michael J., Furman, Philip A., Otto, Michael J.
Gepubliceerd in 2012

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Po...

door Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2008

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

door Lam, Angela M., Edwards, Thomas E., Mosley, Ralph T., Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Gepubliceerd in Antimicrob Agents Chemother (2014)

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

door Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2012

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

door Stuyver, Lieven J., McBrayer, Tamara R., Tharnish, Phillip M., Hassan, Abdalla E. A., Chu, Chung K., Pankiewicz, Krzysztof W., Watanabe, Kyochi A., Schinazi, Raymond F., Otto, Michael J.
Gepubliceerd in 2003

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

door Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2007

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

door Stuyver, Lieven J., Lostia, Stefania, Adams, Marjorie, Mathew, Judy S., Pai, Balakrishna S., Grier, Jason, Tharnish, Phillip M., Choi, Yongseok, Chong, Youhoon, Choo, Hyunah, Chu, Chung K., Otto, Michael J., Schinazi, Raymond F.
Gepubliceerd in 2002

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

door Stuyver, Lieven J., McBrayer, Tamara R., Whitaker, Tony, Tharnish, Phillip M., Ramesh, Mangala, Lostia, Stefania, Cartee, Leanne, Shi, Junxing, Hobbs, Ann, Schinazi, Raymond F., Watanabe, Kyoichi A., Otto, Michael J.
Gepubliceerd in 2004

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

door Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Gepubliceerd in 2010

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

door Stuyver, Lieven J., Whitaker, Tony, McBrayer, Tamara R., Hernandez-Santiago, Brenda I., Lostia, Stefania, Tharnish, Phillip M., Ramesh, Mangala, Chu, Chung K., Jordan, Robert, Shi, Junxing, Rachakonda, Suguna, Watanabe, Kyoichi A., Otto, Michael J., Schinazi, Raymond F.
Gepubliceerd in 2003

Activity and the Metabolic Activation Pathway of the Potent and Selective Hepatitis C Virus Pronucleotide Inhibitor PSI-353661

door Furman, Phillip A., Murakami, Eisuke, Niu, Congrong, Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Bao, Haiying, Tolstykh, Tatiana, Steuer, Holly Micolochick, Keilman, Meg, Zennou, Veronique, Bourne, Nigel, Veselenak, Ronald L., Chang, Wonsuk, Ross, Bruce S., Du, Jinfa, Otto, Michael J., Sofia, Michael J.
Gepubliceerd in 2011

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

door Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2011

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection

door Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S., Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L., Keilman, Meg, Lam, Angela M., Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Gepubliceerd in 2010

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

door Schinazi, Raymond F., Mellors, John, Bazmi, Holly, Diamond, Sharon, Garber, Sena, Gallagher, Karen, Geleziunas, Romas, Klabe, Ron, Pierce, Michael, Rayner, Marlene, Wu, Jing-Tao, Zhang, Hangchun, Hammond, Jennifer, Bacheler, Lee, Manion, Douglas J., Otto, Michael J., Stuyver, Lieven, Trainor, George, Liotta, Dennis C., Erickson-Viitanen, Susan
Gepubliceerd in 2002

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

door Niu, Congrong, Tolstykh, Tatiana, Bao, Haiying, Park, Yeojin, Babusis, Darius, Lam, Angela M., Bansal, Shalini, Du, Jinfa, Chang, Wonsuk, Reddy, P. Ganapati, Zhang, Hai-Ren, Woolley, Joseph, Wang, Li-Quan, Chao, Piyun B., Ray, Adrian S., Otto, Michael J., Sofia, Michael J., Furman, Phillip A., Murakami, Eisuke
Gepubliceerd in 2012

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

door Lam, Angela M., Murakami, Eisuke, Espiritu, Christine, Steuer, Holly M. Micolochick, Niu, Congrong, Keilman, Meg, Bao, Haiying, Zennou, Veronique, Bourne, Nigel, Julander, Justin G., Morrey, John D., Smee, Donald F., Frick, David N., Heck, Julie A., Wang, Peiyuan, Nagarathnam, Dhanapalan, Ross, Bruce S., Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Gepubliceerd in 2010