Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

द्वारा Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Zennou, Veronique, Otto, Michael J., Furman, Phillip A.
प्रकाशित 2011

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

द्वारा King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Samuel C., Otto, Michael J.
प्रकाशित 1999

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

द्वारा King, Robert W., Ladner, Stephanie K., Miller, Thomas J., Zaifert, Katie, Perni, Robert B., Conway, Sameul C., Otto, Michael J.
प्रकाशित 1998

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

द्वारा Mosley, Ralph T., Edwards, Thomas E., Murakami, Eisuke, Lam, Angela M., Grice, Rena L., Du, Jinfa, Sofia, Michael J., Furman, Philip A., Otto, Michael J.
प्रकाशित 2012

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Po...

द्वारा Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M., Whitaker, Tony, Nachman, Tammy, Sofia, Michael A., Wang, Peiyuan, Otto, Michael J., Furman, Phillip A.
प्रकाशित 2008

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

द्वारा Lam, Angela M., Edwards, Thomas E., Mosley, Ralph T., Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
में प्रकाशित Antimicrob Agents Chemother (2014)

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

द्वारा Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J., Furman, Phillip A.
प्रकाशित 2012

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

द्वारा Stuyver, Lieven J., McBrayer, Tamara R., Tharnish, Phillip M., Hassan, Abdalla E. A., Chu, Chung K., Pankiewicz, Krzysztof W., Watanabe, Kyochi A., Schinazi, Raymond F., Otto, Michael J.
प्रकाशित 2003

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

द्वारा Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.
प्रकाशित 2007

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

द्वारा Stuyver, Lieven J., Lostia, Stefania, Adams, Marjorie, Mathew, Judy S., Pai, Balakrishna S., Grier, Jason, Tharnish, Phillip M., Choi, Yongseok, Chong, Youhoon, Choo, Hyunah, Chu, Chung K., Otto, Michael J., Schinazi, Raymond F.
प्रकाशित 2002

Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

द्वारा Stuyver, Lieven J., McBrayer, Tamara R., Whitaker, Tony, Tharnish, Phillip M., Ramesh, Mangala, Lostia, Stefania, Cartee, Leanne, Shi, Junxing, Hobbs, Ann, Schinazi, Raymond F., Watanabe, Kyoichi A., Otto, Michael J.
प्रकाशित 2004

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

द्वारा Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
प्रकाशित 2010

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

द्वारा Stuyver, Lieven J., Whitaker, Tony, McBrayer, Tamara R., Hernandez-Santiago, Brenda I., Lostia, Stefania, Tharnish, Phillip M., Ramesh, Mangala, Chu, Chung K., Jordan, Robert, Shi, Junxing, Rachakonda, Suguna, Watanabe, Kyoichi A., Otto, Michael J., Schinazi, Raymond F.
प्रकाशित 2003

Activity and the Metabolic Activation Pathway of the Potent and Selective Hepatitis C Virus Pronucleotide Inhibitor PSI-353661

द्वारा Furman, Phillip A., Murakami, Eisuke, Niu, Congrong, Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Bao, Haiying, Tolstykh, Tatiana, Steuer, Holly Micolochick, Keilman, Meg, Zennou, Veronique, Bourne, Nigel, Veselenak, Ronald L., Chang, Wonsuk, Ross, Bruce S., Du, Jinfa, Otto, Michael J., Sofia, Michael J.
प्रकाशित 2011

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

द्वारा Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
प्रकाशित 2011

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection

द्वारा Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S., Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L., Keilman, Meg, Lam, Angela M., Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
प्रकाशित 2010

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

द्वारा Schinazi, Raymond F., Mellors, John, Bazmi, Holly, Diamond, Sharon, Garber, Sena, Gallagher, Karen, Geleziunas, Romas, Klabe, Ron, Pierce, Michael, Rayner, Marlene, Wu, Jing-Tao, Zhang, Hangchun, Hammond, Jennifer, Bacheler, Lee, Manion, Douglas J., Otto, Michael J., Stuyver, Lieven, Trainor, George, Liotta, Dennis C., Erickson-Viitanen, Susan
प्रकाशित 2002

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

द्वारा Niu, Congrong, Tolstykh, Tatiana, Bao, Haiying, Park, Yeojin, Babusis, Darius, Lam, Angela M., Bansal, Shalini, Du, Jinfa, Chang, Wonsuk, Reddy, P. Ganapati, Zhang, Hai-Ren, Woolley, Joseph, Wang, Li-Quan, Chao, Piyun B., Ray, Adrian S., Otto, Michael J., Sofia, Michael J., Furman, Phillip A., Murakami, Eisuke
प्रकाशित 2012

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

द्वारा Lam, Angela M., Murakami, Eisuke, Espiritu, Christine, Steuer, Holly M. Micolochick, Niu, Congrong, Keilman, Meg, Bao, Haiying, Zennou, Veronique, Bourne, Nigel, Julander, Justin G., Morrey, John D., Smee, Donald F., Frick, David N., Heck, Julie A., Wang, Peiyuan, Nagarathnam, Dhanapalan, Ross, Bruce S., Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
प्रकाशित 2010