Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure

Tekijä Kishi, Kanako, Ogata, Hiromi, Ogata, Seiji, Mizusawa, Yuri, Okamoto, Eri, Matsumoto, Yukiko, Kokeguchi, Shoji, Shiotani, Masahide
Julkaisussa J Clin Diagn Res (2015)

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

Tekijä Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Julkaisussa mBio (2018)

Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Develop...

Tekijä Aoki, Manabu, Venzon, David J., Koh, Yasuhiro, Aoki-Ogata, Hiromi, Miyakawa, Toshikazu, Yoshimura, Kazuhisa, Maeda, Kenji, Mitsuya, Hiroaki
Julkaistu 2009

Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1

Tekijä Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Ide, Kazuhiko, Das, Debananda, Koh, Yasuhiro, Mitsuya, Hiroaki
Julkaistu 2012

Is human chorionic gonadotropin supplementation beneficial for frozen and thawed embryo transfer in estrogen/progesterone replacement cycles?: A randomized clinical trial

Tekijä Shiotani, Masahide, Matsumoto, Yukiko, Okamoto, Eri, Yamada, Satoshi, Mizusawa, Yuri, Furuhashi, Kohyu, Ogata, Hiromi, Ogata, Seiji, Kokeguchi, Shoji
Julkaisussa Reprod Med Biol (2017)

Anti‐EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half‐life

Tekijä Asano, Ryutaro, Koyama, Noriaki, Hagiwara, Yasuyo, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi
Julkaisussa FEBS Open Bio (2016)

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

Tekijä Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi
Julkaisussa Oncotarget (2018)

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Tekijä Koh, Yasuhiro, Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Das, Debananda, Shafer, Robert W., Ghosh, Arun K., Mitsuya, Hiroaki
Julkaistu 2011

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Tekijä Maeda, Kenji, Nakata, Hirotomo, Koh, Yasuhiro, Miyakawa, Toshikazu, Ogata, Hiromi, Takaoka, Yoshikazu, Shibayama, Shiro, Sagawa, Kenji, Fukushima, Daikichi, Moravek, Joseph, Koyanagi, Yoshio, Mitsuya, Hiroaki
Julkaistu 2004

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

Tekijä Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Julkaisussa Sci Rep (2020)

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, includi...

Tekijä Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S., Martyr, Cuthbert D., Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K., Mitsuya, Hiroaki
Julkaisussa J Virol (2016)

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Tekijä Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Julkaisussa Sci Rep (2020)

Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus I...

Tekijä Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, Kincaid, John F., Boross, Peter, Wang, Yuan-Fang, Tie, Yunfeng, Volarath, Patra, Gaddis, Laquasha, Harrison, Robert W., Weber, Irene T., Ghosh, Arun K., Mitsuya, Hiroaki
Julkaistu 2003

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity aga...

Tekijä Yedidi, Ravikiran S., Garimella, Harisha, Aoki, Manabu, Aoki-Ogata, Hiromi, Desai, Darshan V., Chang, Simon B., Davis, David A., Fyvie, W. Sean, Kaufman, Joshua D., Smith, David W., Das, Debananda, Wingfield, Paul T., Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Julkaistu 2014

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

Tekijä Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Julkaisussa MAbs (2014)

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Tekijä Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Julkaisussa eLife (2017)