Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv): THE CASE OF THE hEx3 DIABODY

por Asano, Ryutaro, Ikoma, Keiko, Shimomura, Ippei, Taki, Shintaro, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Publicado 2011

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

por Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Publicado en Sci Rep (2020)

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

por Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Publicado en MAbs (2014)