Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

One approach to creating more beneficial therapeutic antibodies is to develop bispecific antibodies (bsAbs), particularly IgG-like formats with tetravalency, which may provide several advantages such as multivalent binding to each target antigen. Although the effects of configuration and antibody-fr...

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Publicado no:MAbs
Main Authors: Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623410/
https://ncbi.nlm.nih.gov/pubmed/25517309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29445
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