Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure

Por Kishi, Kanako, Ogata, Hiromi, Ogata, Seiji, Mizusawa, Yuri, Okamoto, Eri, Matsumoto, Yukiko, Kokeguchi, Shoji, Shiotani, Masahide
Publicado no J Clin Diagn Res (2015)

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

Por Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Publicado no mBio (2018)

Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Develop...

Por Aoki, Manabu, Venzon, David J., Koh, Yasuhiro, Aoki-Ogata, Hiromi, Miyakawa, Toshikazu, Yoshimura, Kazuhisa, Maeda, Kenji, Mitsuya, Hiroaki
Publicado em 2009

Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1

Por Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Ide, Kazuhiko, Das, Debananda, Koh, Yasuhiro, Mitsuya, Hiroaki
Publicado em 2012

Is human chorionic gonadotropin supplementation beneficial for frozen and thawed embryo transfer in estrogen/progesterone replacement cycles?: A randomized clinical trial

Por Shiotani, Masahide, Matsumoto, Yukiko, Okamoto, Eri, Yamada, Satoshi, Mizusawa, Yuri, Furuhashi, Kohyu, Ogata, Hiromi, Ogata, Seiji, Kokeguchi, Shoji
Publicado no Reprod Med Biol (2017)

Anti‐EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half‐life

Por Asano, Ryutaro, Koyama, Noriaki, Hagiwara, Yasuyo, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi
Publicado no FEBS Open Bio (2016)

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

Por Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi
Publicado no Oncotarget (2018)

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Por Koh, Yasuhiro, Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Das, Debananda, Shafer, Robert W., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado em 2011

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Por Maeda, Kenji, Nakata, Hirotomo, Koh, Yasuhiro, Miyakawa, Toshikazu, Ogata, Hiromi, Takaoka, Yoshikazu, Shibayama, Shiro, Sagawa, Kenji, Fukushima, Daikichi, Moravek, Joseph, Koyanagi, Yoshio, Mitsuya, Hiroaki
Publicado em 2004

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

Por Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Publicado no Sci Rep (2020)

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, includi...

Por Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S., Martyr, Cuthbert D., Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K., Mitsuya, Hiroaki
Publicado no J Virol (2016)

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Por Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado no Sci Rep (2020)

Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus I...

Por Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, Kincaid, John F., Boross, Peter, Wang, Yuan-Fang, Tie, Yunfeng, Volarath, Patra, Gaddis, Laquasha, Harrison, Robert W., Weber, Irene T., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado em 2003

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity aga...

Por Yedidi, Ravikiran S., Garimella, Harisha, Aoki, Manabu, Aoki-Ogata, Hiromi, Desai, Darshan V., Chang, Simon B., Davis, David A., Fyvie, W. Sean, Kaufman, Joshua D., Smith, David W., Das, Debananda, Wingfield, Paul T., Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Publicado em 2014

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

Por Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Publicado no MAbs (2014)

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Por Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Publicado no eLife (2017)