Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

We identified a novel spirodiketopiperazine (SDP) derivative, AK602/ONO4128/GW873140, which specifically blocked the binding of macrophage inflammatory protein 1α (MIP-1α) to CCR5 with a high affinity (K(d) of ≈3 nM), potently blocked human immunodeficiency virus type 1 (HIV-1) gp120/CCR5 binding an...

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Autori principali: Maeda, Kenji, Nakata, Hirotomo, Koh, Yasuhiro, Miyakawa, Toshikazu, Ogata, Hiromi, Takaoka, Yoshikazu, Shibayama, Shiro, Sagawa, Kenji, Fukushima, Daikichi, Moravek, Joseph, Koyanagi, Yoshio, Mitsuya, Hiroaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC479103/
https://ncbi.nlm.nih.gov/pubmed/15280474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8654-8662.2004
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