Cargando...
Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate
Following the discovery that hydroxylated derivative 3 (Fig. 1) was one of the oxidative metabolites of the original lead 1, it was found that hydroxylated compound 4 possesses higher in vitro anti-HIV potency than the corresponding non-hydroxylated compound 2. Structural hybridation of 4 with the o...
Guardado en:
| Publicado en: | Bioorg Med Chem Lett |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7597670/ https://ncbi.nlm.nih.gov/pubmed/21256008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.109 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|