Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

Following the discovery that hydroxylated derivative 3 (Fig. 1) was one of the oxidative metabolites of the original lead 1, it was found that hydroxylated compound 4 possesses higher in vitro anti-HIV potency than the corresponding non-hydroxylated compound 2. Structural hybridation of 4 with the o...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Minamoto, Chiaki, Matsunaga, Naoki, Takaoka, Yoshikazu, Nakai, Hisao, Jenkinson, Stephen, Kazmierski, Wieslaw M., Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Fukushima, Daikichi, Maeda, Kenji, Mitsuya, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597670/
https://ncbi.nlm.nih.gov/pubmed/21256008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.109
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