Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

Por Ghosh, Arun K., Brindisi, Margherita, Yen, Yu-Chen, Xu, Xiaoming, Huang, Xiangping, Devasamudram, Thippeswamy, Bilcer, Geoffrey, Lei, Hui, Koelsch, Gerald, Mesecar, Andrew, Tang, Jordan
Publicado no Bioorg Med Chem Lett (2014)

Design, Synthesis and X-ray Structure of Protein-Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

Por Ghosh, Arun K., Hussain, Azhar K., Hong, Lin, Lei, Hui, Liu, Chun-Feng, Devasamudram, Thippeswamy, Weerasena, Vajira, Turner, Robert, Koelsch, Gerald, Bilcer, Geoffrey, Tang, Jordan
Publicado em 2006

Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus I...

Por Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, Kincaid, John F., Boross, Peter, Wang, Yuan-Fang, Tie, Yunfeng, Volarath, Patra, Gaddis, Laquasha, Harrison, Robert W., Weber, Irene T., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado em 2003