Design, Synthesis and X-ray Structure of Protein-Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

[Image: see text] Structure-based design, synthesis and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S(2) and S(3)-active site residues to provide selectivity over memapsin 1 and cathepsin D. Inhibitor 6 has exhibi...

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Hlavní autoři: Ghosh, Arun K., Hussain, Azhar K., Hong, Lin, Lei, Hui, Liu, Chun-Feng, Devasamudram, Thippeswamy, Weerasena, Vajira, Turner, Robert, Koelsch, Gerald, Bilcer, Geoffrey, Tang, Jordan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745614/
https://ncbi.nlm.nih.gov/pubmed/16620080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja058636j
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