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Design, Synthesis and X-ray Structure of Protein-Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors
[Image: see text] Structure-based design, synthesis and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S(2) and S(3)-active site residues to provide selectivity over memapsin 1 and cathepsin D. Inhibitor 6 has exhibi...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745614/ https://ncbi.nlm.nih.gov/pubmed/16620080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja058636j |
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