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Predicting memapsin 2 (β-secretase) hydrolytic activity

Memapsin 2 (BACE1, β-secretase), a membrane aspartic protease, functions in the cleavage of brain β-amyloid precursor protein (APP) leading to the production of β-amyloid. Because the excess level of β-amyloid in the brain is a leading factor in Alzheimer's disease (AD), memapsin 2 is a major t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Xiaoman, Bo, Huang, Zhang, Xuejun C, Hartsuck, Jean A, Tang, Jordan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wiley Subscription Services, Inc., A Wiley Company 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005788/
https://ncbi.nlm.nih.gov/pubmed/20853423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.502
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