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Predicting memapsin 2 (β-secretase) hydrolytic activity
Memapsin 2 (BACE1, β-secretase), a membrane aspartic protease, functions in the cleavage of brain β-amyloid precursor protein (APP) leading to the production of β-amyloid. Because the excess level of β-amyloid in the brain is a leading factor in Alzheimer's disease (AD), memapsin 2 is a major t...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005788/ https://ncbi.nlm.nih.gov/pubmed/20853423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.502 |
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