Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

Designing non-natural antibody formats is a practical method for developing highly functional next-generation antibody drugs, particularly for improving the therapeutic efficacy of cancer treatments. One approach is constructing bispecific antibodies (bsAbs). We previously reported a functional huma...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080790/
https://ncbi.nlm.nih.gov/pubmed/32188928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61840-3
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