Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv): THE CASE OF THE hEx3 DIABODY

Diabodies (Dbs) and tandem single-chain variable fragments (taFv) are the most widely used recombinant formats for constructing small bispecific antibodies. However, only a few studies have compared these formats, and none have discussed their binding kinetics and cross-linking ability. We previousl...

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Detalhes bibliográficos
Main Authors: Asano, Ryutaro, Ikoma, Keiko, Shimomura, Ippei, Taki, Shintaro, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023476/
https://ncbi.nlm.nih.gov/pubmed/21097496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172957
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