Frequency of Sperm DNA Fragmentation According to Selection Method: Comparison and Relevance of a Microfluidic Device and a Swim-up Procedure

af Kishi, Kanako, Ogata, Hiromi, Ogata, Seiji, Mizusawa, Yuri, Okamoto, Eri, Matsumoto, Yukiko, Kokeguchi, Shoji, Shiotani, Masahide
Udgivet i J Clin Diagn Res (2015)

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

af Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet i mBio (2018)

Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Develop...

af Aoki, Manabu, Venzon, David J., Koh, Yasuhiro, Aoki-Ogata, Hiromi, Miyakawa, Toshikazu, Yoshimura, Kazuhisa, Maeda, Kenji, Mitsuya, Hiroaki
Udgivet 2009

Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1

af Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Ide, Kazuhiko, Das, Debananda, Koh, Yasuhiro, Mitsuya, Hiroaki
Udgivet 2012

Is human chorionic gonadotropin supplementation beneficial for frozen and thawed embryo transfer in estrogen/progesterone replacement cycles?: A randomized clinical trial

af Shiotani, Masahide, Matsumoto, Yukiko, Okamoto, Eri, Yamada, Satoshi, Mizusawa, Yuri, Furuhashi, Kohyu, Ogata, Hiromi, Ogata, Seiji, Kokeguchi, Shoji
Udgivet i Reprod Med Biol (2017)

Anti‐EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half‐life

af Asano, Ryutaro, Koyama, Noriaki, Hagiwara, Yasuyo, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi
Udgivet i FEBS Open Bio (2016)

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

af Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi
Udgivet i Oncotarget (2018)

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

af Koh, Yasuhiro, Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Das, Debananda, Shafer, Robert W., Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet 2011

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

af Maeda, Kenji, Nakata, Hirotomo, Koh, Yasuhiro, Miyakawa, Toshikazu, Ogata, Hiromi, Takaoka, Yoshikazu, Shibayama, Shiro, Sagawa, Kenji, Fukushima, Daikichi, Moravek, Joseph, Koyanagi, Yoshio, Mitsuya, Hiroaki
Udgivet 2004

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

af Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Udgivet i Sci Rep (2020)

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, includi...

af Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S., Martyr, Cuthbert D., Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet i J Virol (2016)

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

af Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet i Sci Rep (2020)

Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus I...

af Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, Kincaid, John F., Boross, Peter, Wang, Yuan-Fang, Tie, Yunfeng, Volarath, Patra, Gaddis, Laquasha, Harrison, Robert W., Weber, Irene T., Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet 2003

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity aga...

af Yedidi, Ravikiran S., Garimella, Harisha, Aoki, Manabu, Aoki-Ogata, Hiromi, Desai, Darshan V., Chang, Simon B., Davis, David A., Fyvie, W. Sean, Kaufman, Joshua D., Smith, David W., Das, Debananda, Wingfield, Paul T., Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Udgivet 2014

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

af Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Udgivet i MAbs (2014)

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

af Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Udgivet i eLife (2017)