CBP Is a Dosage-Dependent Regulator of Nuclear Factor-κB Suppression by the Estrogen Receptor

by Nettles, Kendall W., Gil, German, Nowak, Jason, Métivier, Raphaël, Sharma, Vandana B., Greene, Geoffrey L.
Published 2008

Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

by Srinivasan, Sathish, Nwachukwu, Jerome C., Parent, Alex A., Cavett, Valerie, Nowak, Jason, Hughes, Travis S., Kojetin, Douglas J., Katzenellenbogen, John A., Nettles, Kendall W.
Published 2013

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

by Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Published 2010

Structural plasticity in the oestrogen receptor ligand-binding domain

by Nettles, Kendall W, Bruning, John B, Gil, German, O'Neill, Erin E, Nowak, Jason, Guo, Yuee, Kim, Younchang, DeSombre, Eugene R, Dilis, Robert, Hanson, Robert N, Joachimiak, Andrzej, Greene, Geoffrey L
Published 2007

Structural plasticity in the oestrogen receptor ligand-binding domain

by Nettles, Kendall W, Bruning, John B, Gil, German, O'Neill, Erin E, Nowak, Jason, Hughs, Alun, Kim, Younchang, DeSombre, Eugene R, Dilis, Robert, Hanson, Robert N, Joachimiak, Andrzej, Greene, Geoffrey L
Published 2007

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

by Nettles, Kendall W., Bruning, John B., Gil, German, Nowak, Jason, Sharma, Sanjay K., Hahm, Johnnie B., Kulp, Kristen, Hochberg, Richard B., Zhou, Haibing, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Kim, Younchang, Joachmiak, Andrzej, Greene, Geoffrey L.
Published 2008

Predictive features of ligand‐specific signaling through the estrogen receptor

by Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W
Published in Mol Syst Biol (2016)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

by Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M., Shulman, Andrew I., Rance, Mark, Griffin, Patrick R., Bruning, John B., Nettles, Kendall W.
Published in Nat Commun (2015)

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

by Nwachukwu, Jerome C, Srinivasan, Sathish, Bruno, Nelson E, Parent, Alexander A, Hughes, Travis S, Pollock, Julie A, Gjyshi, Olsi, Cavett, Valerie, Nowak, Jason, Garcia-Ordonez, Ruben D, Houtman, René, Griffin, Patrick R, Kojetin, Douglas J, Katzenellenbogen, John A, Conkright, Michael D, Nettles, Kendall W
Published 2014

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

by Srinivasan, Sathish, Nwachukwu, Jerome C., Bruno, Nelson E., Dharmarajan, Venkatasubramanian, Goswami, Devrishi, Kastrati, Irida, Novick, Scott, Nowak, Jason, Cavett, Valerie, Zhou, Hai-Bing, Boonmuen, Nittaya, Zhao, Yuechao, Min, Jian, Frasor, Jonna, Katzenellenbogen, Benita S., Griffin, Patrick R., Katzenellenbogen, John A., Nettles, Kendall W.
Published in Nat Chem Biol (2016)

Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells

by Stender, Joshua D., Nwachukwu, Jerome C., Kastrati, Irida, Kim, Yohan, Strid, Tobias, Yakir, Maayan, Srinivasan, Sathish, Nowak, Jason, Izard, Tina, Erumbi, Rangarajan, Carlson, Kathryn E., Katzenellenbogen, John A., Yao, Xin-Qiu, Grant, Barry J., Leong, Hon S, Lin, Chin-Yo, Frasor, Jonna, Nettles, Kendall W., Glass, Christopher K.
Published in Mol Cell (2017)

Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

by Mediouni, Sonia, Chinthalapudi, Krishna, Ekka, Mary K., Usui, Ippei, Jablonski, Joseph A., Clementz, Mark A., Mousseau, Guillaume, Nowak, Jason, Macherla, Venkat R., Beverage, Jacob N., Esquenazi, Eduardo, Baran, Phil, de Vera, Ian Mitchelle S., Kojetin, Douglas, Loret, Erwann P., Nettles, Kendall, Maiti, Souvik, Izard, Tina, Valente, Susana T.
Published in mBio (2019)

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

by Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L
Published in eLife (2018)