Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

Ligand-binding dynamics control allosteric signaling through the estrogen receptor-α (ERα), but the biological consequences of such dynamic binding orientations are unknown. Here, we compare a set of ER ligands having dynamic binding orientation (dynamic ligands) with a control set of isomers that a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Srinivasan, Sathish, Nwachukwu, Jerome C., Parent, Alex A., Cavett, Valerie, Nowak, Jason, Hughes, Travis S., Kojetin, Douglas J., Katzenellenbogen, John A., Nettles, Kendall W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631275/
https://ncbi.nlm.nih.gov/pubmed/23524984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1214
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