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Exploring the Structural Compliancy vs. Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands
The estrogen receptors (ER) bind with high affinity to many structurally diverse ligands by significantly distorting the contours of their ligand-binding pockets. This raises a question: To what degree is ER able to distinguish between structurally related regioisomers and enantiomers? We have explo...
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| Publicat a: | ACS Chem Biol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5315646/ https://ncbi.nlm.nih.gov/pubmed/28032978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00918 |
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