Exploring the Structural Compliancy vs. Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands

The estrogen receptors (ER) bind with high affinity to many structurally diverse ligands by significantly distorting the contours of their ligand-binding pockets. This raises a question: To what degree is ER able to distinguish between structurally related regioisomers and enantiomers? We have explo...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Sharma, Naina, Carlson, Kathryn E., Nwachukwu, Jerome C., Srinivasan, Sathish, Sharma, Abhishek, Nettles, Kendall W., Katzenellenbogen, John A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315646/
https://ncbi.nlm.nih.gov/pubmed/28032978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00918
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