Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

[Image: see text] We have explored the isoelectronic replacement of the C=C double bond found at the core of many nonsteroidal estrogen ligands with a simple Schiff base (C=N). Di- and triaryl-substituted imine derivatives were conveniently prepared by the condensation of benzophenones with various...

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Detalhes bibliográficos
Main Authors: Liao, Zong-Quan, Dong, Chune, Carlson, Kathryn E., Srinivasan, Sathish, Nwachukwu, Jerome C., Chesnut, Robert W., Sharma, Abhishek, Nettles, Kendall W., Katzenellenbogen, John A., Zhou, Hai-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002130/
https://ncbi.nlm.nih.gov/pubmed/24708493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500268j
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