Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latency. Unfortunately, Tat inhibitors are not clinically availab...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:mBio
Egile Nagusiak: Mediouni, Sonia, Chinthalapudi, Krishna, Ekka, Mary K., Usui, Ippei, Jablonski, Joseph A., Clementz, Mark A., Mousseau, Guillaume, Nowak, Jason, Macherla, Venkat R., Beverage, Jacob N., Esquenazi, Eduardo, Baran, Phil, de Vera, Ian Mitchelle S., Kojetin, Douglas, Loret, Erwann P., Nettles, Kendall, Maiti, Souvik, Izard, Tina, Valente, Susana T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368365/
https://ncbi.nlm.nih.gov/pubmed/30723126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02662-18
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