Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latency. Unfortunately, Tat inhibitors are not clinically availab...

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Bibliografiset tiedot
Julkaisussa:mBio
Päätekijät: Mediouni, Sonia, Chinthalapudi, Krishna, Ekka, Mary K., Usui, Ippei, Jablonski, Joseph A., Clementz, Mark A., Mousseau, Guillaume, Nowak, Jason, Macherla, Venkat R., Beverage, Jacob N., Esquenazi, Eduardo, Baran, Phil, de Vera, Ian Mitchelle S., Kojetin, Douglas, Loret, Erwann P., Nettles, Kendall, Maiti, Souvik, Izard, Tina, Valente, Susana T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368365/
https://ncbi.nlm.nih.gov/pubmed/30723126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02662-18
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