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NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
Understanding how steroid hormones regulate physiological functions has been significantly advanced by structural biology approaches. However, progress has been hampered by significant misfolding of the ligand binding domains in heterologous expression systems and by conformational flexibility that...
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| Главные авторы: | , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659626/ https://ncbi.nlm.nih.gov/pubmed/18344977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.76 |
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