Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

Por Kroker, Alice J., Bruning, John B.
Publicado no PPAR Res (2015)

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function

Por Bersten, David C., Bruning, John B., Peet, Daniel J., Whitelaw, Murray L.
Publicado em 2014

New insights into the evolutionary history of plant sorbitol dehydrogenase

Por Jia, Yong, Wong, Darren CJ, Sweetman, Crystal, Bruning, John B, Ford, Christopher M
Publicado no BMC Plant Biol (2015)

Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine

Por Bruning, John B., Murillo, Ana C., Chacon, Ofelia, Barletta, Raúl G., Sacchettini, James C.
Publicado em 2011

Structure of the Apo Form of Bacillus stearothermophilus Phosphofructokinase

Por Mosser, Rockann, Reddy, Manchi C. M., Bruning, John B., Sacchettini, James C., Reinhart, Gregory D.
Publicado em 2012

Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase

Por Mosser, Rockann, Reddy, Manchi C. M., Bruning, John B., Sacchettini, James C., Reinhart, Gregory D.
Publicado em 2013

Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein

Por Reddy, Manchi C. M., Palaninathan, Satheesh K., Bruning, John B., Thurman, Cory, Smith, Danielle, Sacchettini, James C.
Publicado em 2009

Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis

Por Reddy, Manchi C. M., Breda, Ardala, Bruning, John B., Sherekar, Mukul, Valluru, Spandana, Thurman, Cory, Ehrenfeld, Hannah, Sacchettini, James C.
Publicado em 2014

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

Por van Marrewijk, Laura M., Polyak, Steven W., Hijnen, Marcel, Kuruvilla, Dana, Chang, Mi Ra, Shin, Youseung, Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado no ACS Chem Biol (2015)

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

Por Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado em 2010

Structural plasticity in the oestrogen receptor ligand-binding domain

Por Nettles, Kendall W, Bruning, John B, Gil, German, O'Neill, Erin E, Nowak, Jason, Guo, Yuee, Kim, Younchang, DeSombre, Eugene R, Dilis, Robert, Hanson, Robert N, Joachimiak, Andrzej, Greene, Geoffrey L
Publicado em 2007

Structural plasticity in the oestrogen receptor ligand-binding domain

Por Nettles, Kendall W, Bruning, John B, Gil, German, O'Neill, Erin E, Nowak, Jason, Hughs, Alun, Kim, Younchang, DeSombre, Eugene R, Dilis, Robert, Hanson, Robert N, Joachimiak, Andrzej, Greene, Geoffrey L
Publicado em 2007

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Por Nettles, Kendall W., Bruning, John B., Gil, German, Nowak, Jason, Sharma, Sanjay K., Hahm, Johnnie B., Kulp, Kristen, Hochberg, Richard B., Zhou, Haibing, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Kim, Younchang, Joachmiak, Andrzej, Greene, Geoffrey L.
Publicado em 2008

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

Por Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Publicado em 2011

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Por Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M., Shulman, Andrew I., Rance, Mark, Griffin, Patrick R., Bruning, John B., Nettles, Kendall W.
Publicado no Nat Commun (2015)

Pharmacological Repression of PPARγ Promotes Osteogenesis

Por Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Douglas J., Phinney, Donald G., Bruning, John B., Kamenecka, Theodore M., Griffin, Patrick R.
Publicado no Nat Commun (2015)

Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation

Por Choi, Jang Hyun, Banks, Alexander S., Kamenecka, Theodore M., Busby, Scott A., Chalmers, Michael J., Kumar, Naresh, Kuruvilla, Dana S., Shin, Youseung, He, Yuanjun, Bruning, John B., Marciano, David P., Cameron, Michael D., Laznik, Dina, Jurczak, Michael J., Schürer, Stephan C., Vidović, Dušica, Shulman, Gerald I., Spiegelman, Bruce M., Griffin, Patrick R.
Publicado em 2011

Rare variants in single-minded 1 (SIM1) are associated with severe obesity

Por Ramachandrappa, Shwetha, Raimondo, Anne, Cali, Anna M.G., Keogh, Julia M., Henning, Elana, Saeed, Sadia, Thompson, Amanda, Garg, Sumedha, Bochukova, Elena G., Brage, Soren, Trowse, Victoria, Wheeler, Eleanor, Sullivan, Adrienne E., Dattani, Mehul, Clayton, Peter E., Datta, Vippan, Bruning, John B., Wareham, Nick J., O’Rahilly, Stephen, Peet, Daniel J., Barroso, Ines, Whitelaw, Murray L., Farooqi, I. Sadaf
Publicado em 2013

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features

Por Bonnefond, Amélie, Raimondo, Anne, Stutzmann, Fanny, Ghoussaini, Maya, Ramachandrappa, Shwetha, Bersten, David C., Durand, Emmanuelle, Vatin, Vincent, Balkau, Beverley, Lantieri, Olivier, Raverdy, Violeta, Pattou, François, Van Hul, Wim, Van Gaal, Luc, Peet, Daniel J., Weill, Jacques, Miller, Jennifer L., Horber, Fritz, Goldstone, Anthony P., Driscoll, Daniel J., Bruning, John B., Meyre, David, Whitelaw, Murray L., Froguel, Philippe
Publicado em 2013

Rare variants in single-minded 1 (SIM1) are associated with severe obesity

Por Ramachandrappa, Shwetha, Raimondo, Anne, Cali, Anna M.G., Keogh, Julia M., Henning, Elana, Saeed, Sadia, Thompson, Amanda, Garg, Sumedha, Bochukova, Elena G., Brage, Soren, Trowse, Victoria, Wheeler, Eleanor, Sullivan, Adrienne E., Dattani, Mehul, Clayton, Peter E., Datta, Vipan, Bruning, John B., Wareham, Nick J., O’Rahilly, Stephen, Peet, Daniel J., Barroso, Ines, Whitelaw, Murray L., Farooqi, I. Sadaf
Publicado em 2013