Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein

The cAMP receptor protein (CRP) from Mycobacterium tuberculosis is a cAMP-responsive global transcriptional regulator, responsible for the regulation of a multitude of diverse proteins. We have determined the crystal structures of the CRP·cAMP and CRP·N(6)-cAMP derivative-bound forms of the enzyme t...

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Detalhes bibliográficos
Main Authors: Reddy, Manchi C. M., Palaninathan, Satheesh K., Bruning, John B., Thurman, Cory, Smith, Danielle, Sacchettini, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794773/
https://ncbi.nlm.nih.gov/pubmed/19740754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041343
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