Directed Evolution of the Escherichia coli cAMP Receptor Protein at the cAMP Pocket

The Escherichia coli cAMP receptor protein (CRP) requires cAMP binding to undergo a conformational change for DNA binding and transcriptional regulation. Two CRP residues, Thr(127) and Ser(128), are known to play important roles in cAMP binding through hydrogen bonding and in the cAMP-induced confor...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gunasekara, Sanjiva M., Hicks, Matt N., Park, Jin, Brooks, Cory L., Serate, Jose, Saunders, Cameron V., Grover, Simranjeet K., Goto, Joy J., Lee, Jin-Won, Youn, Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646316/
https://ncbi.nlm.nih.gov/pubmed/26378231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678474
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