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Two-State Allosteric Modeling Suggests Protein Equilibrium as an Integral Component for Cyclic AMP (cAMP) Specificity in the cAMP Receptor Protein of Escherichia coli

Activation of the cAMP receptor protein (CRP) from Escherichia coli is highly specific to its allosteric ligand, cAMP. Ligands such as adenosine and cGMP, which are structurally similar to cAMP, fail to activate wild-type CRP. However, several cAMP-independent CRP variants (termed CRP*) exist that c...

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Detaylı Bibliyografya
Asıl Yazarlar: Youn, Hwan, Koh, Junseock, Roberts, Gary P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446778/
https://ncbi.nlm.nih.gov/pubmed/18456811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00074-08
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