Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis

In Mycobacterium tuberculosis, the carboxylation of acetyl coenzyme A (acetyl-CoA) to produce malonyl-CoA, a building block in long-chain fatty acid biosynthesis, is catalyzed by two enzymes working sequentially: a biotin carboxylase (AccA) and a carboxyltransferase (AccD). While the exact roles of...

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Detalhes bibliográficos
Main Authors: Reddy, Manchi C. M., Breda, Ardala, Bruning, John B., Sherekar, Mukul, Valluru, Spandana, Thurman, Cory, Ehrenfeld, Hannah, Sacchettini, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187906/
https://ncbi.nlm.nih.gov/pubmed/25092705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02574-13
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