DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

The vitamin D receptor (VDR) functions as an obligate heterodimer with the retinoid X receptor (RXR). These nuclear receptors (NRs) are multidomain proteins and it is unclear how various domains interact with one another within the NR heterodimer. Here we show that binding of intact heterodimer to D...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087838/
https://ncbi.nlm.nih.gov/pubmed/21478866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2046
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