Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within the intact Vitamin D Receptor/Retinoid X Receptor Heterodimer

Regulation of nuclear receptor (NR) activity is driven by alterations in the conformational dynamics of the receptor upon ligand binding. Previously we demonstrated that hydrogen/deuterium exchange (HDX) can be applied to determine novel mechanism of action of PPARγ ligands and in predicting tissue...

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Detalhes bibliográficos
Main Authors: Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Garcia-Ordonez, Ruben D., Pascal, Bruce D., Burris, Thomas P., Dodge, Jeffery A., Griffin, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956612/
https://ncbi.nlm.nih.gov/pubmed/20947021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.07.007
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