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Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions
Functional regulation of ligand-activated receptors is driven by alterations in the conformational dynamics of the protein upon ligand binding. Differential hydrogen/deuterium exchange (HDX) coupled with mass spectrometry has emerged as a rapid and sensitive approach for characterization of perturba...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3113475/ https://ncbi.nlm.nih.gov/pubmed/21329427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/epr.10.109 |
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