Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange Mass Spectrometry

AMP-Activated protein kinase (AMPK) monitors cellular energy, regulates genes involved in ATP synthesis and consumption, and is allosterically activated by nucleotides and synthetic ligands. Analysis of the intact enzyme by hydrogen/deuterium exchange mass spectrometry reveals conformational perturb...

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Autori principali: Landgraf, Rachelle R., Goswami, Devrishi, Rajamohan, Francis, Harris, Melissa S., Calabrese, Matthew, Hoth, Lise R., Magyar, Rachelle, Pascal, Bruce D., Chalmers, Michael J., Busby, Scott A., Kurumbail, Ravi, Griffin, Patrick R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825792/
https://ncbi.nlm.nih.gov/pubmed/24076403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.08.023
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