Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves as a pleotropic regulator of whole body energy homoeostasis. AMPK exists as a heterotrimeric complex, composed of a catalytic subunit (α) and two regulatory subunits (β and γ), each present as multiple isoforms. In...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem J
Main Authors: Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764975/
https://ncbi.nlm.nih.gov/pubmed/26635351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20151051
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