Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches

BACKGROUND: Allosteric coupling, which can be defined as propagation of a perturbation at one region of the protein molecule (such as ligand binding) to distant sites in the same molecule, constitutes the most general mechanism of regulation of protein function. However, unlike molecular details of...

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Detaylı Bibliyografya
Asıl Yazarlar: Sayar, Kemal, Uğur, Özlem, Liu, Tong, Hilser, Vincent J, Onaran, Ongun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2422842/
https://ncbi.nlm.nih.gov/pubmed/18454845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-8-23
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