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Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

Transcription factors and other allosteric cell signaling proteins contain a disproportionate number of domains or segments that are intrinsically disordered (ID) under native conditions. In many cases folding of these segments is coupled to binding with one or more of their interaction partners, su...

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Main Authors: Hilser, Vincent J., Thompson, E. Brad
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895946/
https://ncbi.nlm.nih.gov/pubmed/17494761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700329104
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