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Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

Transcription factors and other allosteric cell signaling proteins contain a disproportionate number of domains or segments that are intrinsically disordered (ID) under native conditions. In many cases folding of these segments is coupled to binding with one or more of their interaction partners, su...

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Detalhes bibliográficos
Main Authors: Hilser, Vincent J., Thompson, E. Brad
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895946/
https://ncbi.nlm.nih.gov/pubmed/17494761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700329104
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