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Domain-Opening and Dynamic Coupling in the α-Subunit of Heterotrimeric G Proteins
Heterotrimeric G proteins are conformational switches that turn on intracellular signaling cascades in response to the activation of G-protein-coupled receptors. Receptor activation by extracellular stimuli promotes a cycle of GTP binding and hydrolysis on the G protein α-subunit (Gα). Important con...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3714883/ https://ncbi.nlm.nih.gov/pubmed/23870276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.06.006 |
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