Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits

Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise as disease intervention points, given their signature role as negative regulators of...

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Detalhes bibliográficos
Main Authors: Soundararajan, Meera, Willard, Francis S., Kimple, Adam J., Turnbull, Andrew P., Ball, Linda J., Schoch, Guillaume A., Gileadi, Carina, Fedorov, Oleg Y., Dowler, Elizabeth F., Higman, Victoria A., Hutsell, Stephanie Q., Sundström, Michael, Doyle, Declan A., Siderovski, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359823/
https://ncbi.nlm.nih.gov/pubmed/18434541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801508105
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