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The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face
Regulator of G-protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and are thus crucial to the timing of G protein-coupled receptor (GPCR) signaling. Small molecule inhibition of RGS proteins is an attractive therapeutic approach to diseases involving dysregulated GPCR signalin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2084260/ https://ncbi.nlm.nih.gov/pubmed/17660054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2007.06.002 |
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