Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

“Regulator of G-protein signaling” (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Gα subunits (known as GTPase-accelerating protein or “GAP” activity). RGS2 is unique in its in vitro potency...

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Hlavní autoři: Kimple, Adam J., Soundararajan, Meera, Hutsell, Stephanie Q., Roos, Annette K., Urban, Daniel J., Setola, Vincent, Temple, Brenda R. S., Roth, Bryan L., Knapp, Stefan, Willard, Francis S., Siderovski, David P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740565/
https://ncbi.nlm.nih.gov/pubmed/19478087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024711
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