Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

“Regulator of G-protein signaling” (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Gα subunits (known as GTPase-accelerating protein or “GAP” activity). RGS2 is unique in its in vitro potency...

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Détails bibliographiques
Auteurs principaux: Kimple, Adam J., Soundararajan, Meera, Hutsell, Stephanie Q., Roos, Annette K., Urban, Daniel J., Setola, Vincent, Temple, Brenda R. S., Roth, Bryan L., Knapp, Stefan, Willard, Francis S., Siderovski, David P.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740565/
https://ncbi.nlm.nih.gov/pubmed/19478087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024711
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