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A Two-Stage Differential Hydrogen Deuterium Exchange Method for the Rapid Characterization of Protein/Ligand Interactions

The peroxisome proliferator-activated receptor is a member of the nuclear receptor superfamily of transcriptional regulators. Regulation of the nuclear receptors occurs through changes to the structure and dynamics of the ligand-binding domain. Therefore, the need has arisen for a rapid method capab...

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Bibliographische Detailangaben
Hauptverfasser: Chalmers, Michael J., Busby, Scott A., Pascal, Bruce D., Southern, Mark R., Griffin, Patrick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association of Biomolecular Resource Facilities 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062560/
https://ncbi.nlm.nih.gov/pubmed/17916792
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