Rapid Analysis of Protein Structure and Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

An automated approach for the rapid analysis of protein structure has been developed and used to study acid-induced conformational changes in human growth hormone. The labeling approach involves hydrogen/deuterium exchange (H/D-Ex) of protein backbone amide hydrogens with rapid and sensitive detecti...

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Bibliografiske detaljer
Main Authors: Hamuro, Yoshitomo, Coales, Stephen J., Southern, Mark R., Nemeth-Cawley, Jennifer F., Stranz, David D., Griffin, Patrick R.
Format: Artigo
Sprog:Inglês
Udgivet: The Association of Biomolecular Resource Facilities 2003
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279949/
https://ncbi.nlm.nih.gov/pubmed/13678147
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