Dynamic Structural Changes During Complement C3 Activation Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry

Proteolytic cleavage of component C3 to C3b is a central step in the activation of complement. Whereas C3 is largely biologically inactive, C3b is directly involved in various complement activities. While the recently described crystal structures of C3 and C3b provide a molecular basis of complement...

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Detalhes bibliográficos
Main Authors: Schuster, Michael C., Ricklin, Daniel, Papp, Krisztián, Molnar, Kathleen S., Coales, Stephen J., Hamuro, Yoshitomo, Sfyroera, Georgia, Chen, Hui, Winters, Michael S., Lambris, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453784/
https://ncbi.nlm.nih.gov/pubmed/18456336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.03.010
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