Analysis of Agonist and Antagonist Effects on Thyroid Hormone Receptor Conformation by Hydrogen/Deuterium Exchange

Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable structures without ligand (apo-TR) or with antagonists are not. It remains i...

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Autori principali: Figueira, A. C. M., Saidemberg, D. M., Souza, P. C. T., Martínez, L., Scanlan, T. S., Baxter, J. D., Skaf, M. S., Palma, M. S., Webb, P., Polikarpov, I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033054/
https://ncbi.nlm.nih.gov/pubmed/21106879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0202
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