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Structural Underpinnings of Estrogen Receptor Mutations in Endocrine Therapy Resistance
Estrogen receptor alpha (ERα), a key driver of breast cancer, normally requires estrogen for activation. Mutations that constitutively activate ERα without the need for hormone are frequently found in endocrine therapy-resistant breast cancer metastases and are associated with poor patient outcomes....
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| Pubblicato in: | Nat Rev Cancer |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6252060/ https://ncbi.nlm.nih.gov/pubmed/29662238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41568-018-0001-z |
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