Analogs of Methyl-Piperidinopyrazole (MPP): Antiestrogens with Estrogen Receptor α Selective Activity

Por Zhou, Hai-Bing, Carlson, Kathryn E., Stossi, Fabio, Katzenellenbogen, Benita S., Katzenellenbogen, John A.
Publicado em 2008

Bicyclo[2.2.2]octanes: Close Structural Mimics of the Nuclear Receptor Binding Motif of Steroid Receptor Coactivators

Por Zhou, Hai-Bing, Collins, Margaret L., Gunther, Jillian R, Comninos, John S., Katzenellenbogen, John A.
Publicado em 2007

Imaging progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget

Por Zhou, Hai-Bing, Lee, Jae Hak, Mayne, Christopher G., Carlson, Kathryn E., Katzenellenbogen, John A.
Publicado em 2010

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy

Por Luo, Junjie, Hu, Zhiye, Xiao, Yuan, Yang, Tongxin, Dong, Chune, Huang, Jian, Zhou, Hai-Bing
Publicado no Medchemcomm (2017)

Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins

Por Lu, Yuzhi, Wu, Shuangchan, Yue, Yuan, He, Si, Li, Jun, Tang, Jun, Wang, Wei, Zhou, Hai-Bing
Publicado no ACS Med Chem Lett (2016)

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Por Preston, Sarah, Luo, Junjie, Zhang, Yuezhou, Jabbar, Abdul, Crawford, Simon, Baell, Jonathan, Hofmann, Andreas, Hu, Min, Zhou, Hai-Bing, Gasser, Robin B.
Publicado no Parasit Vectors (2016)

Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity

Por Min, Jian, Wang, Pengcheng, Srinivasan, Sathish, Nwachukwu, Jerome C., Guo, Pu, Huang, Minjian, Carlson, Kathryn E., Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Publicado em 2013

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands

Por Zhang, Silong, Wang, Zhiyong, Hu, Zhiye, Li, Changhao, Tang, Chu, Carlson, Kathryn E., Luo, Junjie, Dong, Chune, Katzenellenbogen, John A., Huang, Jian, Zhou, Hai-Bing
Publicado no ChemMedChem (2017)

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure–activity relationships of estrogen receptor ligands based on bridged oxabicyclic core ar...

Por Zhu, Manghong, Zhang, Chen, Nwachukwu, Jerome C., Srinivasan, Sathish, Cavett, Valerie, Zheng, Yangfan, Carlson, Kathryn E., Dong, Chune, Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Publicado em 2012

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

Por Liao, Zong-Quan, Dong, Chune, Carlson, Kathryn E., Srinivasan, Sathish, Nwachukwu, Jerome C., Chesnut, Robert W., Sharma, Abhishek, Nettles, Kendall W., Katzenellenbogen, John A., Zhou, Hai-Bing
Publicado em 2014

Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo[2.2.1]hept-2-ene-7-oxide()

Por Wang, Pengcheng, Min, Jian, Nwachukwu, Jerome C., Cavett, Valerie, Carlson, Kathryn E., Guo, Pu, Zhu, Manghong, Zheng, Yangfan, Dong, Chune, Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Publicado em 2012

Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2...

Por Zheng, Yangfan, Zhu, Manghong, Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Min, Jian, Carlson, Kathryn E., Wang, Pengcheng, Dong, Chune, Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Publicado no ChemMedChem (2012)

Bisperoxovandium (pyridin‐2‐squaramide) targets both PTEN and ERK1/2 to confer neuroprotection

Por Zhang, Zhi‐Feng, Chen, Juan, Han, Xin, Zhang, Ya, Liao, Hua‐Bao, Lei, Rui‐Xue, Zhuang, Yang, Wang, Ze‐Fen, Li, Zhiqiang, Chen, Jin‐Cao, Liao, Wei‐Jing, Zhou, Hai‐Bing, Liu, Fang, Wan, Qi
Publicado no Br J Pharmacol (2017)

Predictive features of ligand‐specific signaling through the estrogen receptor

Por Nwachukwu, Jerome C, Srinivasan, Sathish, Zheng, Yangfan, Wang, Song, Min, Jian, Dong, Chune, Liao, Zongquan, Nowak, Jason, Wright, Nicholas J, Houtman, René, Carlson, Kathryn E, Josan, Jatinder S, Elemento, Olivier, Katzenellenbogen, John A, Zhou, Hai‐Bing, Nettles, Kendall W
Publicado no Mol Syst Biol (2016)

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

Por Srinivasan, Sathish, Nwachukwu, Jerome C., Bruno, Nelson E., Dharmarajan, Venkatasubramanian, Goswami, Devrishi, Kastrati, Irida, Novick, Scott, Nowak, Jason, Cavett, Valerie, Zhou, Hai-Bing, Boonmuen, Nittaya, Zhao, Yuechao, Min, Jian, Frasor, Jonna, Katzenellenbogen, Benita S., Griffin, Patrick R., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado no Nat Chem Biol (2016)