NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts

Por Wang, Yu, Nordhues, Bryce, Zhong, Dalian, De Guzman, Roberto N.
Publicado em 2010

NMR characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa

Por Chaudhury, Sukanya, Nordhues, Bryce A., Kaur, Kawaljit, Zhang, Na, De Guzman, Roberto N.
Publicado no Biochemistry (2015)

The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate

Por Chatterjee, Srirupa, Zhong, Dalian, Nordhues, Bryce A, Battaile, Kevin P, Lovell, Scott, De Guzman, Roberto N
Publicado em 2011

Protein Cross-linking Capillary Electrophoresis (PXCE) for Protein-Protein Interaction Analysis

Por Ouimet, Claire M., Shao, Hao, Rauch, Jennifer N., Dawod, Mohamed, Nordhues, Bryce, Dickey, Chad A., Gestwicki, Jason E., Kennedy, Robert T.
Publicado no Anal Chem (2016)

Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency

Por Sabbagh, Jonathan J., O'Leary, John C., Blair, Laura J., Klengel, Torsten, Nordhues, Bryce A., Fontaine, Sarah N., Binder, Elisabeth B., Dickey, Chad A.
Publicado em 2014

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Por Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado no Hum Mol Genet (2015)

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules

Por Martin, Mackenzie D., Baker, Jeremy D., Suntharalingam, Amirthaa, Nordhues, Bryce A., Shelton, Lindsey B., Zheng, Dali, Sabbagh, Jonathan J., Haystead, Timothy A.J., Gestwicki, Jason E., Dickey, Chad A.
Publicado no ACS Chem Biol (2016)

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

Por Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A
Publicado no Acta Neuropathol Commun (2015)

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

Por Selenica, Maj-Linda B, Davtyan, Hayk, Housley, Steven B, Blair, Laura J, Gillies, Anne, Nordhues, Bryce A, Zhang, Bo, Liu, Joseph, Gestwicki, Jason E, Lee, Daniel C, Gordon, Marcia N, Morgan, Dave, Dickey, Chad A
Publicado em 2014

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

Por Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R. P., Gestwicki, Jason E., Dickey, Chad A.
Publicado no J Biol Chem (2015)

Hsp90 activator Aha1 drives production of pathological tau aggregates

Por Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.
Publicado no Proc Natl Acad Sci U S A (2017)

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

Por Abisambra, Jose F., Jinwal, Umesh K., Blair, Laura J., O'Leary, John C., Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E., Zhang, Bo, Nordhues, Bryce A., Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A., Dickey, Chad A.
Publicado em 2013

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

Por Karagöz, G. Elif, Duarte, Afonso M.S., Akoury, Elias, Ippel, Hans, Biernat, Jacek, Luengo, Tania Morán, Radli, Martina, Didenko, Tatiana, Nordhues, Bryce A., Veprintsev, Dmitry B., Dickey, Chad A., Mandelkow, Eckhard, Zweckstetter, Markus, Boelens, Rolf, Madl, Tobias, Rüdiger, Stefan G.D.
Publicado no Cell (2014)

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

Por Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens, Stanley M, Dickey, Chad A
Publicado no EMBO J (2016)

Human cyclophilin 40 unravels neurotoxic amyloids

Por Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A., Darling, April, Sullivan, Leia E., Sun, Zheying, Solanki, Parth K., Martin, Mackenzie D., Suntharalingam, Amirthaa, Sabbagh, Jonathan J., Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N., Zweckstetter, Markus, Dickey, Chad A., Koren, John, Blair, Laura J.
Publicado no PLoS Biol (2017)

Imbalance of Hsp70 family variants fosters tau accumulation

Por Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado em 2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Por Blair, Laura J., Nordhues, Bryce A., Hill, Shannon E., Scaglione, K. Matthew, O’Leary, John C., Fontaine, Sarah N., Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L., Muschol, Martin, Uversky, Vladimir N., Klengel, Torsten, Binder, Elisabeth B., Kayed, Rakez, Golde, Todd E., Berchtold, Nicole, Dickey, Chad A.
Publicado em 2013