High-throughput approaches to discover novel immunomodulatory agents for cancer

por McMillin, Douglas W., Mitsiades, Constantine S.
Publicado 2012

Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.

por Cao, Shugeng, McMillin, Douglas W., Tamayo, Giselle, Delmore, Jake, Mitsiades, Constantine S., Clardy, Jon
Publicado 2012

Methyljasmonate Displays In Vitro and In Vivo Activity against Multiple Myeloma Cells

por Klippel, Steffen, Jakubikova, Jana, Delmore, Jake, Ooi, Melissa, McMillin, Douglas, Kastritis, Efstathios, Laubach, Jacob, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado en Br J Haematol (2012)

Emerging treatments of multiple myeloma; beyond IMIDs and bortezomib

por Mitsiades, Constantine S., Hideshima, Teru, Chauhan, Dharminder, McMillin, Douglas W., Klippel, Steffen, Laubach, Jacob P., Munshi, Nikhil C., Anderson, Kenneth C., Richardson, Paul G.
Publicado 2009

Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ

por Reagan, Michaela R., Seib, F. Philipp, McMillin, Douglas W., Sage, Elizabeth K., Mitsiades, Constantine S., Janes, Sam M., Ghobrial, Irene M., Kaplan, David L.
Publicado 2012

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)

por Podar, Klaus, Raab, Marc S., Zhang, Jing, McMillin, Douglas, Breitkreutz, Iris, Tai, Yu-Tzu, Lin, Boris K., Munshi, Nikhil, Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C.
Publicado 2007

Activation, Immune Polarization, and Graft-versus-Leukemia Activity of Donor T-cells are Regulated by Specific Subsets of Donor Bone Marrow Antigen-Presenting Cells in Allogeneic H...

por Li, Jian-Ming, Southerland, Lauren T., Lu, Ying, Darlak, Kataryna A., Giver, Cynthia R., McMillin, Douglas W., Harris, Wayne A.C., Jaye, David L., Waller, Edmund K.
Publicado 2009

Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells

por Weisberg, Ellen, Wright, Renee D., McMillin, Douglas W., Mitsiades, Constantine, Ray, Arghya, Barrett, Rosemary, Adamia, Sophia, Stone, Richard, Galinsky, Ilene, Kung, Andrew L., Griffin, James D.
Publicado 2008

Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

por McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Ooi, Melissa, Klippel, Steffen, Miduturu, Chandrasekhar V., Gray, Nathanael S., Richardson, Paul G., Anderson, Kenneth C., Kung, Andrew L., Mitsiades, Constantine S.
Publicado 2011

Compartment-specific bioluminescence imaging platform for the high-throughput evaluation of antitumor immune function

por McMillin, Douglas W., Delmore, Jake, Negri, Joseph M., Vanneman, Matthew, Koyama, Shohei, Schlossman, Robert L., Munshi, Nikhil C., Laubach, Jacob, Richardson, Paul G., Dranoff, Glenn, Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado 2012

In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465

por Negri, Joseph M., McMillin, Douglas W., Delmore, Jake, Mitsiades, Nicholas, Hayden, Patrick, Klippel, Steffen, Hideshima, Teru, Chauhan, Dharminder, Munshi, Nikhil C., Buser, Carolyn A., Pollard, John, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado 2009

Molecular and cellular effects of NEDD8 activating enzyme (NAE) inhibition in myeloma

por McMillin, Douglas W., Jacobs, Hannah M., Delmore, Jake E., Buon, Leutz, Hunter, Zachary R., Monrose, Val, Yu, Jie, Smith, Peter G., Richardson, Paul G., Anderson, Kenneth C., Treon, Steven P., Kung, Andrew L., Mitsiades, Constantine S.
Publicado 2012

Molecular and cellular effects of multi-targeted CDK inhibition in myeloma: Biological and clinical implications

por McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Buon, Leutz, Jacobs, Hannah M., Laubach, Jacob, Jakubikova, Jana, Ooi, Melissa, Hayden, Patrick, Schlossman, Robert, Munshi, Nikhil C., Lengauer, Christoph, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado 2011

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anti-cancer drug activity

por McMillin, Douglas W., Delmore, Jake, Weisberg, Ellen, Negri, Joseph M., Geer, D. Corey, Klippel, Steffen, Mitsiades, Nicholas, Schlossman, Robert L., Munshi, Nikhil C., Kung, Andrew L., Griffin, James D., Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado 2010

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma

por Jakubikova, Jana, Cervi, David, Ooi, Melissa, Kim, Kihyun, Nahar, Sabikun, Klippel, Steffen, Cholujova, Dana, Leiba, Merav, Daley, John F., Delmore, Jake, Negri, Joseph, Blotta, Simona, McMillin, Douglas W., Hideshima, Teru, Richardson, Paul G., Sedlak, Jan, Anderson, Kenneth C., Mitsiades, Constantine S.
Publicado 2011

Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib

por Ooi, Melissa G., Hayden, Patrick J., Kotoula, Vassiliki, McMillin, Douglas W., Charalambous, Elpida, Daskalaki, Emily, Raje, Noopur S., Munshi, Nikhil C., Chauhan, Dharminder, Hideshima, Teru, Buon, Leutz, Clynes, Martin, O’Gorman, Peter, Richardson, Paul G., Mitsiades, Constantine S., Anderson, Kenneth C., Mitsiades, Nicholas
Publicado 2009

The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia

por Leleu, Xavier, Jia, Xiaoying, Runnels, Judith, Ngo, Hai T., Moreau, Anne-Sophie, Farag, Mena, Spencer, Joel A., Pitsillides, Costas M., Hatjiharissi, Evdoxia, Roccaro, Aldo, O'Sullivan, Garrett, McMillin, Douglas W., Moreno, Daisy, Kiziltepe, Tanyel, Carrasco, Ruben, Treon, Steven P., Hideshima, Teru, Anderson, Kenneth C., Lin, Charles P., Ghobrial, Irene M.
Publicado 2007

Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

por Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L., Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W., Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J., Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R., Treon, Steven P., Mitsiades, Constantine S., Griffin, James D., Liu, Qingsong, Gray, Nathanael S.
Publicado 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

por Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B, Abraham, Brian J, Reddy, Jessica, Ficarro, Scott B, Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Christopher R, Hannett, Nancy M, McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine, Weng, Andrew P, Brown, Jennifer R, Benes, Cyril H., Marto, Jarrod A, Young, Richard A, Gray, Nathanael S.
Publicado en Nature (2014)