Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for presently incurable advanced neoplasias with syste...

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Detalhes bibliográficos
Main Authors: McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Ooi, Melissa, Klippel, Steffen, Miduturu, Chandrasekhar V., Gray, Nathanael S., Richardson, Paul G., Anderson, Kenneth C., Kung, Andrew L., Mitsiades, Constantine S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131271/
https://ncbi.nlm.nih.gov/pubmed/21750699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020226
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