In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465

This study characterized the preclinical anti-myeloma activity of VE465, a low molecular weight pan-Aurora kinase inhibitor. After 96-h drug exposure, several multiple myeloma (MM) cell lines were more sensitive to VE465 compared to non-malignant cells. The anti-MM activity of VE465 was maintained i...

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Autors principals: Negri, Joseph M., McMillin, Douglas W., Delmore, Jake, Mitsiades, Nicholas, Hayden, Patrick, Klippel, Steffen, Hideshima, Teru, Chauhan, Dharminder, Munshi, Nikhil C., Buser, Carolyn A., Pollard, John, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672411/
https://ncbi.nlm.nih.gov/pubmed/19751238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07891.x
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