Molecular and cellular effects of multi-targeted CDK inhibition in myeloma: Biological and clinical implications

Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumor cells in advanced vs. early stages of MM. We hypothesized that a multi-targeted CDK inhibitor with a different spectrum of activity...

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Detalhes bibliográficos
Main Authors: McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Buon, Leutz, Jacobs, Hannah M., Laubach, Jacob, Jakubikova, Jana, Ooi, Melissa, Hayden, Patrick, Schlossman, Robert, Munshi, Nikhil C., Lengauer, Christoph, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042406/
https://ncbi.nlm.nih.gov/pubmed/21223249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08427.x
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